Этот ген кодирует киназу, являющуюся ключевым звеном контрольной точки сборки веретена деления в митозе. Белок локализован в кинетохорах и играет важную роль в ингибировании комплекса стимуляции анафазы, задерживая начало анафазы и обеспечивая надлежащую сегрегацию хромосом. Функция этой протеинкиназы нарушена при многих формах рака.[2]
Повышенная экспрессия BubR1 у мышей расширяет период здоровой жизни.[3]
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